Osmotic Demyelination Syndrome as the Initial Manifestation of a Hyperosmolar Hyperglycemic State

Table 2

Reported cases of CMP associated with HHS.

Author^*	Age yr.	Gender	Glu	Osm	Ketones	Na^∧	Na^ç	MRI	TASA	Outcome
McComb et al. [16]	54	F	954	NS	Negative	169	188	No	NM	Died
O’Malley et al. [17]	49	F	1910	399	Trace	134	166	Yes	9 days	ACFR
Burns et al. [18]	93	M	524	343	Negative	137	140	Yes	2 days	ACFR
Mao et al. [19]	55	M	685	318	Negative	134	NS	Yes	0 days^+	NED
Guerrero et al. [20]	25	M	>700	NS	NS	NS	NS	Yes	NS	NS
This report	47	M	838	320	Negative	133	138	Yes	0 days	NED

Reference.
⁺Patient had history of multiple focal seizures 3 weeks before admission.
CPM, central pontine myelinolysis; HHS, hyperosmolar hyperglycemic state; Glu, glucose on admission; Osm, osmolality; Na^∧, sodium at admission; Na^ç, maximum sodium; MRI, magnetic resonance imaging; TASA, time after admission of symptoms; NM, not mentioned; ACFR, almost complete functional recovery; NED, no evidence of disease.
Glu (mg/dL); Osm (mOsm/kg); Na (mEg/L).