Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Neurological Medicine
Volume 2015 (2015), Article ID 242691, 4 pages
http://dx.doi.org/10.1155/2015/242691
Case Report

The Myotonic Plot Thickens: Electrical Myotonia in Antimuscle-Specific Kinase Myasthenia Gravis

Department of Neurology, Emory University, Atlanta, GA 30329, USA

Received 15 October 2015; Accepted 22 November 2015

Academic Editor: Isabella Laura Simone

Copyright © 2015 Marcus Magnussen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. T. Guptill and D. B. Sanders, “Update on muscle-specific tyrosine kinase antibody positive myasthenia gravis,” Current Opinion in Neurology, vol. 23, no. 5, pp. 530–535, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. D. B. Sanders, K. El-Salem, J. M. Massey, J. McConville, and A. Vincent, “Clinical aspects of MuSK antibody positive seronegative MG,” Neurology, vol. 60, no. 12, pp. 1978–1980, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Zhou, J. McConville, V. Chaudhry et al., “Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients,” Muscle & Nerve, vol. 30, no. 1, pp. 55–60, 2004. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Rostedt Punga, K. Ahlqvist, E. Bartoccioni et al., “Neurophysiological and mitochondrial abnormalities in MuSK antibody seropositive myasthenia gravis compared to other immunological subtypes,” Clinical Neurophysiology, vol. 117, no. 7, pp. 1434–1443, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. S. J. Oh, Y. Hatanaka, S. Hemmi et al., “Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis,” Muscle and Nerve, vol. 33, no. 4, pp. 500–504, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. S.-Y. Moon, S.-S. Lee, and Y.-H. Hong, “Muscle atrophy in muscle-specific tyrosine kinase (MuSK)-related myasthenia gravis,” Journal of Clinical Neuroscience, vol. 18, no. 9, pp. 1274–1275, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. D. E. Stickler, J. M. Massey, and D. B. Sanders, “MuSK-antibody positive myasthenia gravis: clinical and electrodiagnostic patterns,” Clinical Neurophysiology, vol. 116, no. 9, pp. 2065–2068, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. A. R. Punga, R. Flink, H. Askmark, and E. V. Stålberg, “Cholinergic neuromuscular hyperactivity in patients with myasthenia gravis seropositive for MuSK antibody,” Muscle & Nerve, vol. 34, no. 1, pp. 111–115, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. E. Farrugia, R. P. Kennett, D. Hilton-Jones, J. Newsom-Davis, and A. Vincent, “Quantitative EMG of facial muscles in myasthenia patients with MuSK antibodies,” Clinical Neurophysiology, vol. 118, no. 2, pp. 269–277, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Klooster, J. J. Plomp, M. G. Huijbers et al., “Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice,” Brain, vol. 135, no. 4, pp. 1081–1101, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Mori and K. Shigemoto, “Mechanisms associated with the pathogenicity of antibodies against muscle-specific kinase in myasthenia gravis,” Autoimmunity Reviews, vol. 12, no. 9, pp. 912–917, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. E. H. Niks, J. B. M. Kuks, J. H. J. Wokke et al., “Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia,” Muscle & Nerve, vol. 42, no. 2, pp. 283–288, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. Q. Wang, B. Zhang, W.-C. Xiong, and L. Mei, “MuSK signaling at the neuromuscular junction,” Journal of Molecular Neuroscience, vol. 30, no. 1-2, pp. 223–226, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. D. P. Richman, K. Nishi, M. J. Ferns et al., “Animal models of antimuscle-specific kinase myasthenia,” Annals of the New York Academy of Sciences, vol. 1274, no. 1, pp. 140–147, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Cenacchi, P. Valentina, F. Marina, P. Elena, and A. Corrado, “Comparison of muscle ultrastructure in myasthenia gravis with anti-MuSK and anti-AChR antibodies,” Journal of Neurology, vol. 258, no. 5, pp. 746–752, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Martignago, M. Fanin, E. Albertini, E. Pegoraro, and C. Angelini, “Muscle histopathology in myasthenia gravis with antibodies against MuSK and AChR,” Neuropathology and Applied Neurobiology, vol. 35, no. 1, pp. 103–110, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. T. M. Miller, “Differential diagnosis of myotonic disorders,” Muscle & Nerve, vol. 37, no. 3, pp. 293–299, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. C. R. Heatwole and R. T. Moxley III, “The Nondystrophic Myotonias,” Neurotherapeutics, vol. 4, no. 2, pp. 238–251, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Vincent, L. Jacobson, P. Plested et al., “Antibodies affecting ion channel function in acquired neuromyotonia, in seropositive and seronegative myasthenia gravis, and in antibody-mediated arthrogryposis multiplex congenita,” Annals of the New York Academy of Sciences, vol. 841, pp. 482–496, 1998. View at Publisher · View at Google Scholar · View at Scopus
  20. M. L. P. Howse, T. M. Wardell, C. J. Fisher, P. J. B. Tilley, P. F. Chinnery, and L. Bindoff, “Late-onset mitochondrial disorder with electromyographic evidence of myotonia,” Muscle & Nerve, vol. 28, no. 6, pp. 757–759, 2003. View at Publisher · View at Google Scholar · View at Scopus