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Case Reports in Neurological Medicine
Volume 2015 (2015), Article ID 892047, 4 pages
Case Report

Late Occurrence of PML in a Patient Treated for Lymphoma with Immunomodulatory Chemotherapies, Bendamustine, Rituximab, and Ibritumomab Tiuxetan

Department of Neurology, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03766, USA

Received 7 October 2014; Revised 7 January 2015; Accepted 15 January 2015

Academic Editor: Jacqueline A. Pettersen

Copyright © 2015 Michael A. Lane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


PML caused by John Cunningham (JC) virus is a rare but an increasingly recognized entity. With the advent of newer immunomodulatory therapies with monoclonal antibodies, there is an increasing incidence of PML. Initially concern was restricted to patients treated for multiple sclerosis with natalizumab but more case reports are being reported during treatment for other conditions like Crohn’s disease and lymphoma with agents such as rituximab. We report the case of a 66-year-old woman who developed PML a year after completion of therapy with rituximab, ibritumomab, and bendamustine.