Case Report

Neurological Complications of Middle East Respiratory Syndrome Coronavirus: A Report of Two Cases and Review of the Literature

Table 2

Patients with neurological complications of Middle East Respiratory Syndrome Coronavirus (MERS-CoV).

PatientAge/sexPresenting symptomsComorbiditiesDiagnosisTreatmentsOutcomeCause of death

Patient 1 [4]74/MAtaxia, vomiting, confusion, and feverDiabetes, hypertension,
and dyslipidemia
Acute disseminated encephalomyelitis
Broad-spectrum antibiotics, oseltamivir,
bronchodilators, methylprednisolone, intravenous sedation, neuromuscular blockers, inhaled nitric oxide, vasopressors, renal replacement therapy, peginterferon alpha-2b and ribavirin
DeathDeep coma, poor overall condition, and worsening cardiovascular
and respiratory status

Patient 2 [4]57/MFlu-like illness, fever, and a gangrenous toeDiabetes, hypertension, and peripheral vascular diseaseBilateral anterior
cerebral artery stroke
Broad-spectrum antibioticsDeathSevere shock, acute kidney injury, and multiple cardiac arrests

Patient 3 [4]45/MProductive cough, dyspnea, rigors, fever, and diarrheaDiabetes, hypertension, chronic kidney disease, and ischemic heart diseaseEncephalitisBroad-spectrum antibiotics, oseltamivir, renal replacement therapy, neuromuscular blockers, nitric oxide, vasopressors, peginterferon alpha-2b and ribavirinRecoveryNot applicable

Patient 434/FFever, generalized bone pain, and fatigueDiabetes mellitusIntracerebral hemorrhageIntravenous hydration, tazocin, azithromycin, mannitol, and dexamethasoneDeathMultiorgan failure and intracerebral hemorrhage with massive brain edema

Patient 528/MFever, generalized myalgia, dizziness, and productive coughNoneCritical illness polyneuropathyAzithromycin, oseltamivir, antibiotics, intravenous immunoglobulins, and physiotherapyRecoveryNot applicable