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Case Reports in Neurological Medicine
Volume 2016, Article ID 6108234, 11 pages
Case Report

Simultaneous Combined Myositis, Inflammatory Polyneuropathy, and Overlap Myasthenic Syndrome

1Department of Neurology, Nerve-Muscle Unit, CHU Bordeaux (Groupe Hospitalier Pellegrin), place Amélie-Raba-Léon, 33000 Bordeaux, France
2Department of Neurology, Centre de Référence “Neuropathies Périphériques Rares”, CHU Limoges, 2 avenue Martin Luther King, 87042 Limoges, France
3Department of Neurology, CHU Bretonneau, 2 boulevard Tonnellé, 37044 Tours, France
4Department of Neurology, CHU Poitiers, 2 rue de la Milétrie, 86021 Poitiers, France

Received 17 August 2016; Accepted 16 October 2016

Academic Editor: Tapas Kumar Banerjee

Copyright © 2016 Stéphane Mathis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Immune-mediated neuromuscular disorders include pathologies of the peripheral nervous system, neuromuscular junction, and muscles. If overlap syndromes (or the association of almost two autoimmune disorders) are recognized, the simultaneous occurrence of several autoimmune neuromuscular disorders is rare. We describe two patients presenting the simultaneous occurrence of inflammatory neuropathy, myositis, and myasthenia gravis (with positive acetylcholine receptor antibodies). For each patient, we carried out a pathological analysis (nerve and muscle) and an electrophysiological study (and follow-up). To our knowledge, this is the first description of such a triple immune-mediated neuromuscular syndrome. We compared our observations with a few other cases of simultaneous diagnosis of two inflammatory neuromuscular disorders.