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Case Reports in Neurological Medicine
Volume 2018, Article ID 2768493, 16 pages
Case Report

Hypothermia in Multiple Sclerosis: Beyond the Hypothalamus? A Case Report and Review of the Literature

1Division of Clinical Neuroscience, University of Nottingham School of Medicine, Nottingham, UK
2Department of Neurology, Nottingham University Hospitals NHS Trust, Nottingham, UK

Correspondence should be addressed to Bruno Gran; ku.shn.hun@narg.onurb

Received 18 August 2017; Revised 6 January 2018; Accepted 6 February 2018; Published 21 March 2018

Academic Editor: Isabella Laura Simone

Copyright © 2018 Francesco Berti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hypothermia is a rare and poorly understood complication of Multiple Sclerosis (MS). We report on a 66-year-old patient currently with Secondary Progressive MS (SP-MS) who developed unexplained hypothermia associated with multiple hospitalisations and we review the literature on this topic. In our case, magnetic resonance imaging (MRI) of the brain failed to highlight hypothalamic disease, but spinal MRI identified a number of spinal cord lesions. Given the incidence and clinical significance of spinal involvement in MS and the hypothermic disturbances observed in high Spinal Cord Injury (SCI), we hypothesise that upper spinal cord pathology, along with hypothalamic and brainstem dysfunctions, can contribute to hypothermia.