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Case Reports in Neurological Medicine
Volume 2018, Article ID 5157275, 3 pages
Case Report

Parkinsonism Associated with Pathological 123I-FP-CIT SPECT (DaTSCAN) Results as the Initial Manifestation of Sporadic Creutzfeldt-Jakob Disease

1Department of Neurology, University General Hospital, Ciudad Real, Spain
2Intensive Care Unit, University General Hospital, Ciudad Real, Spain

Correspondence should be addressed to Sira Carrasco García de León; moc.liamg@97ocsarracaris

Received 7 December 2017; Revised 1 April 2018; Accepted 29 April 2018; Published 31 May 2018

Academic Editor: Isabella Laura Simone

Copyright © 2018 Sira Carrasco García de León et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sporadic Creutzfeldt-Jakob disease (sCJD) is a type of progressive, subacute encephalopathy associated with spongiform degeneration of the central nervous system. sCJD includes a broad and heterogeneous spectrum of clinical variants, but extrapyramidal symptoms and signs at disease onset were rarely reported. We describe a case of unilateral parkinsonism associated with pathological 123I-ioflupane SPECT (DaTSCAN) results as the initial manifestation of M129V subtype sCJD patient. To the best of our knowledge, only 2 cases of Creutzfeldt-Jakob disease demonstrating nigrostriatal dopaminergic deficits in vivo using DaTSCAN have been published in the literature.