TY - JOUR A2 - Gontkovsky, Samuel T. AU - Jaafar, Nesreen AU - Khoueiry, Maria AU - Khoury, Samia J. AU - Makki, Achraf PY - 2021 DA - 2021/01/28 TI - Rare Case of Spinal Neurosarcoidosis with Concomitant Epidural Lipomatosis SP - 5952724 VL - 2021 AB - Introduction. Spinal neurosarcoidosis is a rare disease that can manifest as myelopathy, radiculopathy, or cauda equine syndrome. Spinal epidural lipomatosis is also a rare condition resulting from overgrowth of epidural fat tissue causing compressive myelopathy. To our knowledge, there are no reports linking epidural lipomatosis and spinal neurosarcoidosis. Case Report. We describe a case of progressive myelitis in the presence of concomitant spinal neurosarcoidosis and epidural lipomatosis which was a challenging diagnosis with complete response to treatment after addressing both diseases. Both etiologies are inflammatory in nature and share similar expression of inflammatory factors such as TNF-α and IL-1β. Conclusion. The common inflammatory process involved in these two diseases might explain a pathophysiological interconnection between both diseases that may underlie their concomitant development in our patient. If these two diseases are interconnected, in their pathophysiological mechanism remains a hypothesis that will need further investigation. SN - 2090-6668 UR - https://doi.org/10.1155/2021/5952724 DO - 10.1155/2021/5952724 JF - Case Reports in Neurological Medicine PB - Hindawi KW - ER -