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Case Reports in Obstetrics and Gynecology
Volume 2013, Article ID 356560, 5 pages
Case Report

Liver Transplantation during Pregnancy for Acute Liver Failure due to HBV Infection: A Case Report

1Department of Obstetrics, University Hospital of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland
2Department of Surgery and Transplantation, University Hospital of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland
3Department of Gastroenterology and Hepatology, University Hospital of Zurich and Swiss HPB Center, Switzerland

Received 8 September 2013; Accepted 28 October 2013

Academic Editors: P. Kovacs and P. Schuetze

Copyright © 2013 Nina Kimmich et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Acute hepatic failure during pregnancy is a life-threatening situation for the mother and fetus and might need a super-urgent liver transplantation. Many pregnancies with positive outcomes are reported after a previous liver transplantation before the pregnancy, but only a few of them are mentioned with transplantation during pregnancy. In these few cases, fetal outcome is mostly adverse. Experience with liver failure during pregnancy and its management is still deficient and needs to be approved. For sure, patients need to be treated in highly qualified centers in a multidisciplinary approach. We present a case of successful super-urgent liver transplantation during the second trimester of pregnancy after acute hepatic failure due to an acute hepatitis B infection with positive maternal and fetal outcome. Liver transplantation during pregnancy due to an acute liver failure can be a life-saving procedure for the mother and fetus. An early initiated maternal therapy with antiviral drugs and immunoglobulins seems to be safe and able to prevent fetal infection and immunosuppressive therapy after transplantation seems to be well tolerated. Nevertheless, fetal outcome differs widely and long-term outcome is deficiently known.