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Case Reports in Obstetrics and Gynecology
Volume 2013 (2013), Article ID 858501, 6 pages
http://dx.doi.org/10.1155/2013/858501
Case Report

Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor in a 16-Year-Old Single Woman: A Case Report and Literature Review

Ahmed Abu-Zaid,1 Ayman Azzam,2 Lama Abdulhamid Alghuneim,1 Mona Tarek Metawee,1 Tarek Amin,3 and Turki Omar Al-Hussain4

1College of Medicine, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi Arabia
2Department of General Surgery, Faculty of Medicine, Alexandria University, Alexandria 21526, Egypt
3Department of Surgical Oncology, King Faisal Specialist Hospital and Research Center (KFSH&RC), P.O. Box 3354, Riyadh 11211, Saudi Arabia
4Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center (KFSH&RC), P.O. Box 3354, Riyadh 11211, Saudi Arabia

Received 14 May 2013; Accepted 18 June 2013

Academic Editors: S. Z. A. Badawy, X. Deffieux, L. Nilas, and M. G. Porpora

Copyright © 2013 Ahmed Abu-Zaid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. H. Young and R. E. Scully, “Ovarian Sertoli-Leydig cell tumors. A clinicopathological analysis of 207 cases,” American Journal of Surgical Pathology, vol. 9, no. 8, pp. 543–569, 1985. View at Google Scholar · View at Scopus
  2. C. Zaloudek and H. J. Norris, “Sertoli-Leydig tumors of the ovary. A clinicopathologic study of 64 intermediate and poorly differentiated neoplasms,” American Journal of Surgical Pathology, vol. 8, no. 6, pp. 405–418, 1984. View at Google Scholar · View at Scopus
  3. L. M. Roth, M. C. Anderson, and A. D. T. Govan, “Sertoli-Leydig cell tumors: a clinicopathologic study of 34 cases,” Cancer, vol. 48, no. 1, pp. 187–197, 1981. View at Google Scholar · View at Scopus
  4. C. S. Weng, M. Y. Chen, T. Y. Wang et al., “Sertoli-Leydig cell tumors of the ovary: a Taiwanese gynecologic oncology group study,” Taiwanese Journal of Obstetrics & Gynecology, vol. 52, no. 1, pp. 66–70, 2013. View at Google Scholar
  5. R. H. Young and R. E. Scully, “Sex cord-stromal, steroid cell, and other ovarian tumors,” in Blaustein's Pathology of Female Genital Tract, R. J. Kurman, Ed., p. 929, Springer, New York, NY, USA, 5th edition, 2002. View at Google Scholar
  6. K. M. Zanotti, “The clinical manifestations and diagnosis of Sertoli-Leydig cell tumors of the ovary,” CME Journal of Gynecologic Oncology, vol. 7, no. 2, pp. 129–133, 2002. View at Google Scholar · View at Scopus
  7. R. H. Osborn and M. E. Yannone, “Plasma androgens in the normal and androgenic female: a review,” Obstetrical & Gynecological Survey, vol. 26, no. 3, pp. 195–228, 1971. View at Publisher · View at Google Scholar
  8. F. T. Prunty, “Hirsutism, virilism and apparent virilism and their gonadal relationship. II,” Journal of Endocrinology, vol. 38, no. 2, pp. 203–227, 1967. View at Google Scholar · View at Scopus
  9. C. M. de Oliveira Franzin, M. L. Kraft, D. Faundes, L. C. Zeferino, M. Alvarenga, and E. F. Marussi, “Detection of ovarian Sertoli-Leydig cell tumors exclusively by color Doppler sonography,” Journal of Ultrasound in Medicine, vol. 25, no. 10, pp. 1327–1330, 2006. View at Google Scholar · View at Scopus
  10. M. Nouriani, J. C. Felix, and L. Dubeau, “Histogenesis and histopathological characteristics of Sertoli-Leydig cell tumors,” CME Journal of Gynecologic Oncology, vol. 7, no. 2, pp. 114–120, 2002. View at Google Scholar · View at Scopus
  11. W. G. McCluggage and R. H. Young, “Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors,” Seminars in Diagnostic Pathology, vol. 22, no. 1, pp. 3–32, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. R. A. Bhat, Y. K. Lim, Y. N. Chia, and K. L. Yam, “Sertoli-Leydig cell tumor of the ovary: analysis of a single institution database,” Journal of Obstetrics and Gynaecology Research, vol. 39, no. 1, pp. 305–310, 2013. View at Publisher · View at Google Scholar
  13. V. W. Chen, B. Ruiz, J. L. Killeen, T. R. Coté, X. C. Wu, and C. N. Correa, “Pathology and classification of ovarian tumors,” Cancer, vol. 97, supplement 10, pp. 2631–2642, 2003. View at Google Scholar
  14. D. R. Meldrum and G. E. Abraham, “Peripheral and ovarian venous concentrations of various steroid hormones in virilizing ovarian tumors,” Obstetrics and Gynecology, vol. 53, no. 1, pp. 36–43, 1979. View at Google Scholar · View at Scopus
  15. E. B. Mendelson, M. Bohm-Velez, N. Joseph, and H. L. Neiman, “Gynecologic imaging: comparison of transabdominal and transvaginal sonography,” Radiology, vol. 166, no. 2, pp. 321–324, 1988. View at Google Scholar · View at Scopus
  16. E. H. Yanushpolsky, D. L. Brown, and B. L. Smith, “Localization of small ovarian Sertoli-Leydig cell tumors by transvaginal sonography with color Doppler,” Ultrasound in Obstetrics & Gynecology, vol. 5, no. 2, pp. 133–135, 1995. View at Google Scholar · View at Scopus
  17. H. P. Cathro and M. H. Stoler, “The utility of calretinin, inhibin, and WT1 immunohistochemical staining in the differential diagnosis of ovarian tumors,” Human Pathology, vol. 36, no. 2, pp. 195–201, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. W. G. McCluggage, M. McKenna, and H. A. McBride, “CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord-stromal tumors,” International Journal of Gynecological Pathology, vol. 26, no. 3, pp. 322–327, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Gui, D. Cao, K. Shen et al., “A clinicopathological analysis of 40 cases of ovarian Sertoli-Leydig cell tumors,” Gynecologic Oncology, vol. 127, no. 2, pp. 384–389, 2012. View at Publisher · View at Google Scholar
  20. J. Brown, A. K. Sood, M. T. Deavers, L. Milojevic, and D. M. Gershenson, “Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted?” Gynecologic Oncology, vol. 113, no. 1, pp. 86–90, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Sigismondi, A. Gadducci, D. Lorusso et al., “Ovarian Sertoli-Leydig cell tumors. A retrospective MITO study,” Gynecologic Oncology, vol. 125, no. 3, pp. 673–676, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. F. Y. Chen, B. C. Sheu, M. C. Lin, S. N. Chow, and H. H. Lin, “Sertoli-Leydig cell tumor of the ovary,” Journal of the Formosan Medical Association, vol. 103, no. 5, pp. 388–391, 2004. View at Google Scholar · View at Scopus
  23. P. Sachdeva, R. Arora, C. Dubey, A. Sukhija, M. Daga, and D. K. Singh, “Sertoli-Leydig cell tumor: a rare ovarian neoplasm. Case report and review of literature,” Gynecological Endocrinology, vol. 24, no. 4, pp. 230–234, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. B. J. Roth, A. Greist, P. S. Kubilis, S. D. Williams, and L. H. Einhorn, “Cisplatin-based combination chemotherapy for disseminated germ cell tumors: long-term follow-up,” Journal of Clinical Oncology, vol. 6, no. 8, pp. 1239–1247, 1988. View at Google Scholar · View at Scopus