Vulvar Metastasis from Bladder Cancer

Table 1

Review of the literature-clinicopathological features of metastatic urothelial carcinoma to the vulva.

Authors	Number	Age (years)	Symptoms	Primary	Interval	Sites of metastasis	Tissue involvement	Other metastases	Treatment	Follow-up
Dehner (1973) [3]	2	48	Hematuria and disuria	Urothelial urethra	Synchronous	Labia majora	NR	No	Vulvovaginectomy with bilateral inguinal lymphadenopathy	Living well at 130 months
		57	Painless vulvar nodule	Urothelial urethra	19 months	Perineum	NR	No	Pelvic exenteration	Died of disease at 58 months
Mazur et al. (1984) [4]	1	NR	NR	NR	NR	NR	NR	NR	NR	NR
Cohen et al. (1988) [9]	1	NR	Painless nodule	Kidney	>8 months	Vulvae	NR	No	NR	NR
Lerner et al. (1999) [5]	1	78	Painful nodule	Urothelial bladder	Synchronous	Vulvae	NR	No	NR	NR
Boardman et al. (2001) [10]	2	71	Pagetoid vulvae	Urothelial CIS bladder	12 months	Vulvae	NR	Yes	Radical vulvectomy	Died of disease at 65 months
		64	Pagetoid vulvae	Urothelial CIS bladder	Synchronous	Vulvae	NR	Yes	Radical vulvectomy + chemotherapy	Follow-up at 8 months: no disease
Neto et al. (2003) [6]	2	54	Cyst	Bladder	2 months	Labia majora	ep + der + subc	Yes	Xrt	Died of disease at 2 months
		53	Mass	Urethra	12 months	Labia majora	ep + der + subc	Yes	Xrt	Died of disease at 12 months
Our case (2015)	1	63	Painless nodule	Bladder	12 months	Vulvae	NR	Yes

der: dermis; ep: epidermis; mo: month; NR: not reported, Sepi: squamous epithelium; Subc: subcutis; Xrt: radiotherapy.