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Case Reports in Obstetrics and Gynecology
Volume 2015, Article ID 612824, 5 pages
Case Report

Serous Ovarian Carcinoma Recurring as Malignant Mixed Mullerian Tumor

1Department of Pathology, Cerrahpasa School of Medicine, Istanbul University, 34098 Istanbul, Turkey
2Department of Obstetrics and Gynecology, Cerrahpasa School of Medicine, Istanbul University, 34098 Istanbul, Turkey

Received 12 August 2015; Accepted 23 November 2015

Academic Editor: Yoshio Yoshida

Copyright © 2015 Demir Hale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Only five cases of recurrence of malignant mixed Mullerian tumor (carcinosarcoma) from the ovarian carcinoma have been published in the literature to our knowledge. A 64-year-old woman first underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy because of pelvic mass. Histological diagnosis was serous papillary carcinoma of the left ovary. After six courses of chemotherapy, CA125 level returned to normal range. However, she had persistent multiple mediastinal and para-aortic lymphadenopathies in spite of additional six courses of chemotherapy. Then she underwent the second operation about 2 years after primary surgery. Multiple excisional biopsies were taken from subcutaneous tissue, over the bowels and the left external iliac artery. The histopathological diagnosis which was confirmed by immunohistochemical study was malignant mixed Mullerian tumor for all metastatic foci. A rare case of ovarian serous papillary carcinoma recurring as malignant mixed Mullerian tumor is reported.