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Case Reports in Obstetrics and Gynecology
Volume 2015, Article ID 890610, 3 pages
Case Report

Drug-Induced Thrombocytopenia following a Transvaginal Oocyte Retrieval for In Vitro Fertilization

1Stanford University Medical Center, 900 Welch Road, Suite 20, Palo Alto, CA 94304, USA
2Stanford University Medical Center, 450 Broadway Street, Redwood City, CA 94063, USA
3BloodCenter of Wisconsin, Medical College of Wisconsin, P.O. Box 2178, Milwaukee, WI 53201, USA
4Stanford University Medical Center, 900 Welch Road, Suite 350 MC 5800, Palo Alto, CA 94304, USA

Received 21 January 2015; Accepted 17 February 2015

Academic Editor: Babatunde A. Gbolade

Copyright © 2015 Ioanna A. Comstock et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Drug-induced immune thrombocytopenia has been associated with hundreds of medications and can lead to devastating consequences for the patient. We present a case of a healthy 33-year-old female undergoing in vitro fertilization who developed a severe drug-induced thrombocytopenia, petechiae, and a large hemoperitoneum after receiving Cefazolin antibiotic prophylaxis for a transvaginal oocyte retrieval. The patient was admitted to the intensive care unit for resuscitation with blood products. The presence of drug-dependent platelet antibodies to Cefazolin was confirmed serologically.