Metastatic Malignant Ovarian Steroid Cell Tumor: A Case Report and Review of the Literature

Table 2

Documented cases of malignant steroid cell tumor NOS with references, ordered by year of publication.

Reference	Age at diagnosis	Presentation	Initial surgery	Stage at diagnosis	Postoperative treatment	Recurrence	Survival (months)
Hayes and Scully (18 cases) [1]	2.5 to 80 (average 43)	Hirsutism, virilization, postmenopausal bleeding, menorrhagia, abdominal swelling	TAH, BSO, or USO	I–IV	Vincristine, actinomycin D, mitotane, cisplatin, doxorubicin, cyclophosphamide, 5-fluorouracil, radiation	Yes in 4 of 18 cases	5–228
Donovan et al. [3]	66	Abdominal enlargement, leg edema, hypertension	TAH, BSO, omentectomy, appendectomy, PPALND, debulking	IV	Cisplatin, methotrexate, vinblastine then enalapril, ketoconazole, etoposide, ifosfamide	Yes	Not reported but died of disease
Wang et al. [9]	50	Hirsutism	TAH, BSO, omentectomy, PPALND	IIA	GnRH-agonist	None	32
Wang et al. [6]	48	Hirsutism	TAH, BSO, omentectomy, PPALND	IIA	None	None	6
Brewer and Shevlin [10]	58	Pelvic pain, virilization	TAH, BSO, PPALND	IIIC	BEP with progression after second cycle then GnRH-agonist	Yes	11
Garduño-López et al. [11]	34	Abdominal pain, hirsutism	Hepatic trisegmentectomy	IV	BEP	None	6
Saida et al. [7]	28	Virilization	USO	IA	None	Unknown	Unknown
Murhekar et al. [12]	31	Hirsutism, oligomenorrhea	Resection of isolated mass on pelvic mesentery	IA	None	Unknown	Unknown
Jiang et al. [13]	21	Amenorrhea, virilization	TAH, BSO, omentectomy, debulking of peritoneal metastases	IIIC	BEP	Yes	10
Li et al. [14]	29	Back and leg pain	USO	IV	Docetaxel and nedaplatin	Yes	6

TAH: total abdominal hysterectomy.
BSO: bilateral salpingo-oophorectomy.
PPALND: pelvic and para-aortic lymph node dissection.
USO: unilateral salpingo-oophorectomy.
GnRH: gonadotropin-releasing hormone.
BEP: bleomycin, etoposide, and cisplatin.