TY - JOUR A2 - Geary, Michael AU - Awadalla, Michael AU - Patwardhan, Manasi AU - Alsamsam, Adham AU - Imran, Nashat PY - 2017 DA - 2017/03/15 TI - Management of Liddle Syndrome in Pregnancy: A Case Report and Literature Review SP - 6279460 VL - 2017 AB - Liddle syndrome is an autosomal dominant genetic condition that causes hypertension and hypokalemia due to a gain-of-function mutation in the SCNN1B or SCNN1G genes which code for the epithelial sodium channel in the kidney. This leads to increased sodium and water reabsorption causing hypertension. We report a case of a 27-year-old pregnant woman who was admitted for hypertension and hypokalemia and later diagnosed and treated for Liddle syndrome using amiloride. Maintaining a high suspicion of Liddle syndrome in pregnancy is essential in such cases to be able to adequately and effectively treat the hypertension. Due to physiological effects of pregnancy, the dose of amiloride may need to be increased as gestational age progresses up to a maximum dose of 30 mg orally per day. SN - 2090-6684 UR - https://doi.org/10.1155/2017/6279460 DO - 10.1155/2017/6279460 JF - Case Reports in Obstetrics and Gynecology PB - Hindawi KW - ER -