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Case Reports in Obstetrics and Gynecology
Volume 2017, Article ID 6279460, 4 pages
Case Report

Management of Liddle Syndrome in Pregnancy: A Case Report and Literature Review

1Department of Obstetrics and Gynecology, Wayne State University, Detroit Medical Center, Detroit, MI, USA
2Division of Nephrology and Hypertension, Department of Internal Medicine, Wayne State University, Detroit Medical Center, Detroit, MI, USA

Correspondence should be addressed to Nashat Imran; ude.enyaw.dem@narmin

Received 23 November 2016; Accepted 26 February 2017; Published 15 March 2017

Academic Editor: Michael Geary

Copyright © 2017 Michael Awadalla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Liddle syndrome is an autosomal dominant genetic condition that causes hypertension and hypokalemia due to a gain-of-function mutation in the SCNN1B or SCNN1G genes which code for the epithelial sodium channel in the kidney. This leads to increased sodium and water reabsorption causing hypertension. We report a case of a 27-year-old pregnant woman who was admitted for hypertension and hypokalemia and later diagnosed and treated for Liddle syndrome using amiloride. Maintaining a high suspicion of Liddle syndrome in pregnancy is essential in such cases to be able to adequately and effectively treat the hypertension. Due to physiological effects of pregnancy, the dose of amiloride may need to be increased as gestational age progresses up to a maximum dose of 30 mg orally per day.