Triple Synchronous Primary Neoplasms of the Cervix, Endometrium, and Ovary: A Rare Case Report and Summary of All the English PubMed-Indexed Literature

Table 1

A summary table of all existing cases of triple or more synchronous primary neoplasms of the female genital system ( = 13).

Ref	Author	Year	Age (yr)	Presentation	Site	Tumor histology	Tx	FU (mon)	Outcome
				Anorexia	Ovary	Papillary serous cystadenocarcinoma
[14]	Matlock et al.	1982	77	Abdominal pain	Ovary	Mucinous cystadenocarcinoma	CT	4	DOD
				Weight loss	Uterus	papillary adenocarcinoma with psammoma bodies
				NM	Ovary	Mucinous adenocarcinoma
[2]	Ayhan et al.	1992	NM		Uterus	Endometrioid adenocarcinoma	NM	28	DOD
					Cervix	Carcinoma in situ
				Vaginal bleeding	Ovary	Endometrioid adenocarcinoma
[7]	Jobo et al.	1997	35		Uterus	Endometrioid adenocarcinoma	CT	25	NED
					Cervix	Carcinoma in situ
				Vaginal bleeding	Ovary	Clear-cell carcinoma
[1]	Ree et al.	2003	46		Ovary	Borderline mucinous cystadenoma	CT	17	NED
					Uterus	Endometrioid adenocarcinoma
				Pelvic pain	Ovary	Mucinous adenocarcinoma
[9]	Isin Dogan Ekici et al.	2006	56	Vaginal bleeding	Uterus	Endometrioid adenocarcinoma	CT	24	NED
					Uterus	Leiomyosarcoma
				Menorrhagia	Ovary	Mucinous adenocarcinoma
[11]	Phupong et al.	2007	50		Ovary	Low malignant potential	RT	3	DOD
					Uterus	Endometrioid adenocarcinoma
					Cervix	Endocervical adenosquamous carcinoma
				Spotting	Ovary	Brenner tumor
[13]	Pekin et al.	2007	62	Vaginal bleeding	Ovary	Granulosa tumor	NM	NM	NM
					Cervix	Squamous cell carcinoma
				Postmenopausal bleeding	Ovary	Mucinous adenocarcinoma
[8]	Saglam et al.	2008	63		FT	Early papillary adenocarcinoma	CT	12	NED
				Abdominal distention	Uterus	Endometrioid adenocarcinoma
					Cervix	Endocervical adenocarcinoma
				Pelvic pain	Ovary	Papillary serous adenocarcinoma
				Lower abdominal distention	FT	Microinvasive carcinoma in situ
[10]	Atasever et al.	2009	50		FT	Microinvasive carcinoma in situ	CT	29	DOD
					Uterus	Intraepithelial adenocarcinoma
					Cervix	Endocervical in situ carcinoma
				Fatigue	Ovary	Mucinous, clear cell, and endometrioid carcinoma
[6]	Hale et al.	2011	49	Ankle edema	Uterus	Endometrioid adenocarcinoma	NM	NM	NM
				Abdominal distention	Cervix	Endometrioid adenocarcinoma
				Abdominal distention	Ovary	Leydig cell
[12]	Zhang and Lerwill	2011	79	Abdominal pain	Uterus	Myxoid leiomyosarcoma	None	10	NED
				Dyspnea	Uterus	Mucinous adenocarcinoma
				Metrorrhagia	Ovary	Serous adenocarcinoma
[4]	Takatori et al.	2014	50		Uterus	Endometrioid adenocarcinoma	CT	18	NED
					Cervix	Endometrioid adenocarcinoma
				Pelvic pain	Ovary	Mucinous adenocarcinoma
[5]	Chiofalo et al.	2016	38	Vaginal bleeding	Uterus	Endometrioid adenocarcinoma	CT	18	NED
					Cervix	Mucinous adenocarcinoma
				Abdominal distention	Ovary	Clear-cell carcinoma
	Our case	2017	55	Abdominal pain	Uterus	Endometrioid adenocarcinoma	None	3	DP
				Vaginal bleeding	Cervix	Poorly differentiated squamous cell carcinoma

Ref: reference; yr: years; Tx: therapy; mon: months; CT: chemotherapy; RT: radiotherapy; NM: not mentioned; DOD: died of disease; NED: no evidence of disease; DP: disease progression.