Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology

Table 1

Clinical cases.

Case	Age	Respiratory symptoms	Primary surgery for leiomyoma	Radiology	Final diagnosis	Microscopy and Immunohistochemistry	Cytogenetic evaluation	Treatment	Follow-up
1	49	Asymptomatic	Total hysterectomy, 10 years ago	Miliary pattern; PET: weak FDG uptake	CT-guided biopsy	Smooth muscle tumor, SMA+, desmin +, hormonal receptors+, low Ki-67	Lung tumor: 19q13 and 22q12 deletions	Bilateral salpingo-oophorectomy and Letrozole.	9 months, stable
2	48	Cough	Total hysterectomy, 13 years ago	Multiple pulmonary nodules; PET: weak FDG uptake	CT-guided biopsy	Smooth muscle tumor, SMA+, desmin +, hormonal receptors+, low ki-67	Lung tumor and primary leiomyoma: 19q13 and 22q12 deletions	Bilateral salpingo-oophorectomy	6 months, stable

PET= positron emission tomography; FDG= Fluorodeoxyglucose; CT= computed tomography; SMA=smooth muscle actin.