Refer Age Respiratory symptoms Primary surgery for leiomyoma Radiology Final diagnosis Microscopy and Immunohistochemistry Cytogenetic evaluation Treatment Follow-up Nurettin et al. [1 ] 41 Dyspnea Myomectomy, Multiple pulmonary nodules VATS biopsy Smooth muscle tumor, SMA+, desmin +, hormonal receptors+, low ki-67 Not applicable Bilateral salpingo-oophorectomy, total hysterectomy and Progesterone 5 years, stable Ma et al. [3 ] 45 Asymptomatic Myomectomy, Multiple pulmonary nodules Aspiration Biopsy Smooth muscle tumor, SMA+, desmin +, hormonal receptors+, ki-67=1% Not applicable Pulmonary wedge resection 5 months, stable Chen et al. [5 ] 32 Chest tightness and labored breathing Myomectomy, Miliary nodules Thoracoscopic Biopsy Spindle cells, SMA+, desmin +, hormonal receptors+ Not applicable Tamoxifen 3 months, stable Lee et al. [8 ] 52 Asymptomatic Vaginal hysterectomy, Multiple lung cavitations and nodules Needle Biopsy Spindle cells, SMA+, desmin +, hormonal receptors+ Not applicable GnRH Agonist 15 months, stable Ras et al. [9 ] 53 Asymptomatic Myomectomy, Multiple pulmonary nodules Thoracotomy Biopsy Bland smooth muscle cells, desmin +, hormonal receptors+, low ki-67 Not applicable Subtotal hysterectomy, bilateral salpingo-ooforectomy, removal of the tumors from parametria and appendectomy and pulmonary wedge resection by thoracotomy Not applicable Ottlakan et al. [10 ] 36 Asymptomatic Hysterectomy, Multiple pulmonary nodules Core Biopsy Smooth muscle cells, SMA+ Lung nodules: 19q22q deletion Pulmonary wedge resection and cautery resection, through mini-thoracotomy (seven procedures) Many recurrences Patré et al. [11 ] 76 Acute respiratory distress Total hysterectomy, Multiple pulmonary nodules and pleural effusion Surgical biopsy Spindle cells, SMA+, desmin +, hormonal receptors+, caldesmon+ Not applicable Resection of pulmonary nodules, removal of trochanteric lesion and aromatase inhibitors 45 months, stable Khan et al. [14 ] 47 Shortness pf breath and chest pain Cervical hysterectomy, Multiple pulmonary nodules CT guided biopsy and VATS biopsy Smooth muscle tumor, SMA+, desmin +, hormonal receptors+, HMB45-, CD34-, EMA- Lung nodules: Loss of 19 and 22 and deletion of 1p VATS wedge resection and anastrozole 12 months, stable Bakkensen et al. [15 ] 46 Asymptomatic Total hysterectomy, Multiple pulmonary nodules CT guided biopsy Bland spindle cells, SMA+, desmin +, hormonal receptors+ Not applicable Bilateral salpingo-ooforectomy, resection of pelvic mass, opportunistic appendectomy and letrozole 2 years, stable Zhong et al. [17 ] 51 Asymptomatic Myomectomy, Multiple pulmonary nodules CT guided biopsy Spindle-shaped cells, SMA+, desmin+, hormonal receptors+, CD34-, S100-, HMB45-, Ki-67<20% Not applicable Removal of lumbar spine tumor and Tamoxifen 5 months, stable
