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Case Reports in Obstetrics and Gynecology
Volume 2018, Article ID 7927362, 4 pages
https://doi.org/10.1155/2018/7927362
Case Report

Sertoli-Leydig Cell Tumour and DICER1 Mutation: A Case Report and Review of the Literature

1St George’s Hospital, UK
2St George’s Hospital and the Royal Marsden Hospital, UK

Correspondence should be addressed to B. Wormald; ten.shn@dlamrow.neb

Received 20 June 2018; Accepted 6 September 2018; Published 25 September 2018

Academic Editor: Giampiero Capobianco

Copyright © 2018 B. Wormald et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sertoli-Leydig cell tumours of the ovary (SLCT) are rare tumours predominantly caused by mutations in the DICER1 gene. We present a patient with a unilateral SLCT who had an underlying germline DICER1 gene mutation. We discuss the underlying pathology, risks, and screening opportunities available to those with a mutation in this gene as SLCT is only one of a multitude of other tumours encompassing DICER1 syndrome. The condition is inherited in an autosomal dominant fashion. As such, genetic counselling is a key component of the management of women with SLCT.