Synchronous Choriocarcinoma and Epithelioid Trophoblastic Tumor Concurring at the Cesarean Scar: A Case Report and Review of the Literature

Figure 4

Features of epithelioid trophoblastic tumor and choriocarcinoma in the third time abdominal wall tumor resection. Most of the tumor tissue (ETT) (a ×40; b ×100) was characterized by nodular growth of medium-sized rumor cells arranged in nests or cords to large masses. The cells were relatively uniform. Nuclear atypia was generally moderate. Extensive necrosis appeared often. Small part of tumor tissue (CC) displayed a dimorphic population of trophoblast cells (syncytiotroblastic cells and cytotrophoblastic or intermediate trophoblastic cells) with marked hemorrhage and necrosis(e ×40; f ×100). Immunohistochemically, tumor cells were strongly positive for p63 (c ×40) and negative for inhibin-alpha (d ×40) in ETT, while they reacted positively to inhibin-alpha (h ×40 ) but negatively to p63 (g ×40) in CC.

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