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Case Reports in Oncological Medicine
Volume 2012, Article ID 120727, 4 pages
http://dx.doi.org/10.1155/2012/120727
Case Report

Pure Large Cell Neuroendocrine Carcinoma of Ovary: A Rare Clinical Entity and Review of Literature

1Department of Gynaecologic Oncology, Kidwai Memorial Institute of Oncology, Dr. M. H. Mari Gowda Road, Bengaluru 560029, India
2Department of Pathology, Kidwai Memorial Institute of Oncology, Dr. M. H. Mari Gowda Road, Bengaluru 560029, India

Received 28 August 2012; Accepted 11 November 2012

Academic Editors: A. Goodman, Y. Yamada, and N. Yoshimura

Copyright © 2012 P. N. Shakuntala et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Large cell neuroendocrine carcinoma (LCNEC) of the ovary is a rare tumor and is now included in the World Health Organization tumor classification. Its prognosis is generally very poor even when the diagnosis is made at an early stage. We report a case of pure large cell neuroendocrine tumour of ovary, appearing 9 months following laparoscopic type I hysterectomy, bilateral pelvic lymph node dissection with ovarian preservation of anatomically normal looking ovaries performed for a cervical biopsy diagnosis of cervical intraepithelial neoplasia grade III with foci of invasion. The rarity lies in the rapid onset (9 months) of a large tumor following conservation of an anatomically normal ovaries. Surgical debulking and five cycles of chemotherapy (Etoposide and Cisplatin) were administered to the woman. She is on followup with no clinical or radiological evidence of disease recurrence for 6 months.