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Case Reports in Oncological Medicine
Volume 2012, Article ID 137291, 4 pages
http://dx.doi.org/10.1155/2012/137291
Case Report

Visceral Kaposi's Sarcoma Related to Human Herpesvirus-8 in Liver Transplant Recipient: Case Report and Literature Review

1Department of Medical Oncology, Hassan II University Hospital, Fez, Morocco
2Department of Transplantation, University Hospitals of Geneva, 1205 Geneva, Switzerland
3Department of Pathology, University Hospitals of Geneva, 1205 Geneva, Switzerland
4Department of Medical Oncology, University Hospitals of Geneva, 1205 Geneva, Switzerland

Received 2 September 2012; Accepted 9 December 2012

Academic Editors: S. Aksoy and J. Keller

Copyright © 2012 H. Benhammane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Kaposi’s sarcoma (KS) in transplant recipients is about 400 to 500 times rate in the general population. It is strongly associated to Human herpesvirus-8 (HHV-8) infection which has been found in 95% of KS lesions. The optimal approach to managing posttransplantation KS is to reduce or discontinue immunosuppressive therapy but this strategy carries a risk of the acute rejection of the graft. Recently, the use of an mTOR inhibitor has added new opportunities for KS treatment and prevention. Case Report. We report a case of 24 years-old Turkish woman with visceral HHV-8-associated Kaposi's sarcoma after orthotopic liver transplantation. Conclusion. Posttransplantation KS is considered an experimental model of virus induced tumor suggesting the usefulness of HHV-8 screening in transplant recipient and donor. Therapeutic approaches are complex and require a multidisciplinary team.