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Case Reports in Oncological Medicine
Volume 2012, Article ID 343491, 4 pages
http://dx.doi.org/10.1155/2012/343491
Case Report

Salvage Therapy for Refractory Aids-Related Primary Central Nervous System Lymphoma

Department of Internal Medicine, Clínica y Maternidad Suizo, Argentina, Avenida Pueyrredon 1461, C1118AAE Buenos Aires, Argentina

Received 28 July 2012; Accepted 26 August 2012

Academic Editors: K. Aogi, J. I. Mayordomo, and G. P. Vandoros

Copyright © 2012 Hugo Ferro and Eduardo Parino. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A 27-year-old male patient presented with speech disorders and multiple brain masses on MRI evaluation. He tested positive for HIV. A sterotactic biopsy diagnosed primary central nervous system lymphoma (diffuse large B-cell lymphoma). After two cycles of high-dose metotrexate (HD-MTX-)-based chemotherapy, the tumor progressed. He underwent whole brain radiotherapy achieving complete response. Six cycles of consolidating immunochemotherapy with rituximab-temozolomide were administered after radiation. Forty-three months after remission, he has not recurred and his neurological status is optimal. Younger HIV patients with refractory PCNSL and preserved immune function can face salvage therapy successfully achieving long term remissions with no remarkable neurotoxicity.