Case Report

Turcot Syndrome: A Synchronous Clinical Presentation of Glioblastoma Multiforme and Adenocarcinoma of the Colon

Table 1

Summary of selected reported cases with high-grade glioma and adenocarcinoma of the colon.

Authors (year)No. of casesCNS tumorsOther associated tumorsInterval between the diagnosis of high-grade glioma and colonic adenocarcinomaSurvival rate after the diagnosis of high-grade glioma

Agostini et al. (2005) [6]1Right frontal giant-cell GBM (i) Adenocarcinoma of the ampullary region
(ii) Adenomas of the transverse and sigmoid colon
9 monthsNot reported
Castillo and Wilson (2002) [7]1Left frontoparietal GBMMultiple colonic polyps with adenocarcinomaSame time as diagnosisNot reported
Chung et al. (2012) [8]1Right parietotemporal GBM(i) Ovarian cystadenocarcinoma
(ii) Adenocarcinoma in sigmoid colon
12 yearsStill alive at the age of 25 at the time of reporting the case
Eguchi et al. (1993) [9]1Recurring grade 3 astrocytoma in the right parietal lobeAdenocarcinoma of the colonSame time as diagnosisOne year
Kleinerman et al. (2012) [10]1Malignant astrocytoma (grade III) of the frontal lobe (i) Recurring colon cancer
(ii) Carcinoma of the right groin
(iii) Nodular basal cell of the right nose and the left cheek
12 yearsOne year
Lusis et al. (2010) [11]3GBMColorectal adenocarcinoma3, 6, and 6 months, respectivelyTwo of the patients died after 44 and 55 months of diagnosis, and the third was still alive at the time of writing the article. Survived >29 months since diagnosis
McLaughlin et al. (1998) [12]1(i) Medulloblastoma
(ii) Right parietal GBM
Adenocarcinoma of the colonAbout 10 yearsA few months
Radin et al. (1984) [13]1GBM of the cervical spinal cordAdenocarcinoma of the descending colon4 months6 months
Schroder et al. (1983) [14]1GBM of the left frontal lobeCarcinoma of the jejunum5 yearsThe patient died from brain herniation due to GBM acute presentation. The diagnosis was made from autopsy
Takayama et al. (1989) [15]1Initial diagnosis was grade I astrocytoma of left frontal lobe, and the recurrence was GBMAdenocarcinoma of the ascending colon6 months18 months