Atypical Reversible Leucoencephalopathy Syndrome after Bevacizumab/Folfox Regimen for Metastatic Colon Cancer

Table 2

Authors	Patient; (Age, sex)	Localization	Chemotherapy	Symptoms	MRI	Treatment	Outcomes
Matsunaga et al., 2012 [30]	43 W	Metastatic sigmoid cancer	Modified Folfox 6	Nausea, headache, disturbed consciousness, visual disturbance, seizures; Status epilepticus; hypertension	Bilateral occipital lesions on MRI	No medication for hypertension	No neurologic sequelae; MRI brain resolved; 40 days later
Nagata et al., 2009 [31]	35 W	Metastatic sigmoid	Folfox regimen	Convulsions, headache, and visual disturbance; hypertension	Bilateral lesions on posterior lobes on MRI	Antihypertensive therapy and anticonvulsive therapy	Complete resolution of symptoms; MRI changes resolved; 30 days later
Sharief and Perry, 2009 [32]	59 M	Metastatic colon cancer	Folfox 6 regimen	Status epilepticus; BP: 156/98	Bilateral frontal cortical lesion on MRI; noncontrast CT scan of the head was normal	Seizure medications	Complete recovery in 24 h; MRI brain resolved; two weeks later
Pinedo et al., 2007 [33]	62 W	Metastatic adenocarcinoma of rectum	Folfox + Bevacizumab	Seizures,; altered mental status,; bilateral lower extremity weakness; BP: 190/88	Lesions on posterior lobes on MRI	Diazepam	Complete resolution on MRI 10 days later
Skelton et al., 2007 [34]	1 F	Metastatic adenocarcinoma of rectum	Folfox	Seizures; Altered mental status	Hyperintensity in the white matter of the posterior hemispheres		Resolution of lesion on repeated MRI