Symptomatic Histologically Proven Necrosis of Brain following Stereotactic Radiation and Ipilimumab in Six Lesions in Four Melanoma Patients

Table 1

Overview of the clinical history of the four patients.

Patient	1	2	3	4	Average months
MBM number	1	3	4	3
MBM with RNB	1	1	3	1
Dose of ipilimumab (mg/kg)	3	3	3	Blinded*
Reinduction of ipilimumab	Yes	No	No	No
Type of RT	SRS	SRS + WBRT	SRT	SRT + WBRT
Stereotactic radiation dose (total dose Gy/#)	20/1	18/1	40/8	45/10
BRAF treatment before RNB	Yes	Yes	No	No
Time from first ipi to RNB (months)	46	11	6, 7, 13	11	94/6 = 15
Time from SRT to RNB (months)	10	7	9, 10, 16	14	66/6 = 11
Further intracranial progression at last FU	No	Yes	No	No
Status at last FU; months following first diagnosis of MBM	NED at 28	PD at 23	DONC at 16	PD at 14	81/4 = 20