Case Reports in Oncological Medicine / 2014 / Article / Tab 1

Case Report

Symptomatic Histologically Proven Necrosis of Brain following Stereotactic Radiation and Ipilimumab in Six Lesions in Four Melanoma Patients

Table 1

Overview of the clinical history of the four patients.

Patient 1234Average months

MBM number 1343
MBM with RNB 1131
Dose of ipilimumab (mg/kg) 333Blinded*
Reinduction of ipilimumabYesNoNoNo
Type of RTSRSSRS + WBRTSRTSRT + WBRT
Stereotactic radiation dose (total dose Gy/#)20/118/140/845/10
BRAF treatment before RNB YesYesNoNo
Time from first ipi to RNB (months)46116, 7, 131194/6 = 15
Time from SRT to RNB (months)1079, 10, 161466/6 = 11
Further intracranial progression at last FUNo YesNoNo
Status at last FU; months following first diagnosis of MBMNED at 28PD at 23DONC at 16 PD at 1481/4 = 20