Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Oncological Medicine
Volume 2014, Article ID 615895, 5 pages
http://dx.doi.org/10.1155/2014/615895
Case Report

Renal Medullary Carcinoma: Case Report of an Aggressive Malignancy with Near-Complete Response to Dose-Dense Methotrexate, Vinblastine, Doxorubicin, and Cisplatin Chemotherapy

1Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
2Division of General Internal Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA
3Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
4Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15232, USA

Received 16 June 2014; Accepted 5 August 2014; Published 19 August 2014

Academic Editor: Jose I. Mayordomo

Copyright © 2014 Ali Imran Amjad et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. J. Davis Jr., F. K. Mostofi, and I. A. Sesterhenn, “Renal medullary carcinoma: the seventh sickle cell nephropathy,” American Journal of Surgical Pathology, vol. 19, no. 1, pp. 1–11, 1995. View at Publisher · View at Google Scholar · View at Scopus
  2. R. A. Avery, J. E. Harris, C. J. Davis Jr., D. S. Borgaonkar, J. C. Byrd, and R. B. Weiss, “Renal medullary carcinoma: clinical and therapeutic aspects of a newly described tumor,” Cancer, vol. 78, no. 1, pp. 128–132, 1996. View at Google Scholar
  3. I. C. Watanabe, A. Billis, M. S. Guimarães et al., “Renal medullary carcinoma: report of seven cases from Brazil,” Modern Pathology, vol. 20, no. 9, pp. 914–920, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. C. L. Coogan, C. F. McKiel Jr., M. J. Flanagan, T. P. Bormes, and T. G. Matkov, “Renal medullary carcinoma in patients with sickle cell trait,” Urology, vol. 51, no. 6, pp. 1049–1050, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. W. G. Noguera-Irizarry, H. Hibshoosh, and K. P. Papadopoulos, “Renal medullary carcinoma: case report and review of the literature,” The American Journal of Clinical Oncology: Cancer Clinical Trials, vol. 26, no. 5, pp. 489–492, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. A. A. Hakimi, P. T. Koi, P. M. Milhoua et al., “Renal medullary carcinoma: the Bronx experience,” Urology, vol. 70, no. 5, pp. 878–882, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. W. K. Rathmell and J. P. Monk, “High-dose-intensity mvac for advanced renal medullary carcinoma: report of three cases and literature review,” Urology, vol. 72, no. 3, pp. 659–663, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. C. N. Sternberg, P. H. M. de Mulder, J. H. Schornagel et al., “Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: european organization for research and treatment of cancer protocol no. 30924,” Journal of Clinical Oncology, vol. 19, no. 10, pp. 2638–2646, 2001. View at Google Scholar · View at Scopus
  9. J. Stahlschmidt, C. Cullinane, P. Roberts, and S. V. Picton, “Renal medullary carcinoma: prolonged remission with chemotherapy, immunohistochemical characterisation and evidence of bcr/abl rearrangement,” Medical and Pediatric Oncology, vol. 33, no. 6, pp. 551–557, 1999. View at Google Scholar
  10. L. Simpson, X. He, M. Pins et al., “Renal medullary carcinoma and ABL gene amplification,” Journal of Urology, vol. 173, no. 6, pp. 1883–1888, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. J. J. Strouse, M. Spevak, A. K. Mack, R. J. Arceci, D. Small, and D. M. Loeb, “Significant responses to platinum-based chemotherapy in renal medullary carcinoma,” Pediatric Blood & Cancer, vol. 44, no. 4, pp. 407–411, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. E. A. Ronnen, G. V. Kondagunta, and R. J. Motzer, “Medullary renal cell carcinoma and response to therapy with bortezomib,” Journal of Clinical Oncology, vol. 24, no. 9, article e14, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Walsh, D. R. Kelly, Y. N. Vaid, L. M. Hilliard, and G. K. Friedman, “Complete response to carboplatin, gemcitabine, and paclitaxel in a patient with advanced metastatic renal medullary carcinoma,” Pediatric Blood and Cancer, vol. 55, no. 6, pp. 1217–1220, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. L. M. Pirich, P. Chou, and D. O. Walterhouse, “Prolonged survival of a patient with sickle cell trait and metastatic renal medullary carcinoma,” Journal of Pediatric Hematology/Oncology, vol. 21, no. 1, pp. 67–69, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Mariño-Enríquez, W. Ou, C. B. Weldon, J. A. Fletcher, and A. R. Pérez-Atayde, “ALK rearrangement in sickle cell trait-associated renal medullary carcinoma,” Genes Chromosomes and Cancer, vol. 50, no. 3, pp. 146–153, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. Q. Liu, S. Galli, R. Srinivasan, W. M. Linehan, M. Tsokos, and M. J. Merino, “Renal medullary carcinoma: molecular, immunohistochemistry, and morphologic correlation,” The American Journal of Surgical Pathology, vol. 37, no. 3, pp. 368–374, 2013. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Calderaro, J. Moroch, G. Pierron et al., “SMARCB1/INI1 inactivation in renal medullary carcinoma,” Histopathology, vol. 61, no. 3, pp. 428–435, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. A. Klochendler-Yeivin, E. Picarsky, and M. Yaniv, “Increased DNA damage sensitivity and apoptosis in cells lacking the Snf5/Ini1 subunit of the SWI/SNF chromatin remodeling complex,” Molecular and Cellular Biology, vol. 26, no. 7, pp. 2661–2674, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Medjkane, E. Novikov, I. Versteege, and O. Delattre, “The tumor suppressor hSNF5/INI1 modulates cell growth and actin cytoskeleton organization,” Cancer Research, vol. 64, no. 10, pp. 3406–3413, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. I. Versteege, S. Medjkane, D. Rouillard, and O. Delattre, “A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle,” Oncogene, vol. 21, no. 42, pp. 6403–6412, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. M. A. Swartz, J. Karth, D. T. Schneider, R. Rodriguez, J. B. Beckwith, and E. J. Perlman, “Renal medullary carcinoma: clinical, pathologic, immunohistochemical, and genetic analysis with pathogenetic implications,” Urology, vol. 60, no. 6, pp. 1083–1089, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. X. J. Yang, J. Sugimura, M. S. Tretiakova et al., “Gene expression profiling of renal medullary carcinoma: potential clinical relevance,” Cancer, vol. 100, no. 5, pp. 976–985, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. E. M. Schaeffer, T. J. Guzzo, K. A. Furge et al., “Renal medullary carcinoma: Molecular, pathological and clinical evidence for treatment with topoisomerase-inhibiting therapy,” BJU International, vol. 106, no. 1, pp. 62–65, 2010. View at Publisher · View at Google Scholar · View at Scopus