Oral Metastasis of Metaplastic Breast Carcinoma in a Patient with Neurofibromatosis 1

Table 1

Immunohistochemical features observed in both carcinoma and sarcomatoid components and in both breast and mandibular tumors.

Antibody	Clone	Breast Cancer		Oral metastasis
		Carcinoma	Sarcomatous
ER	SP1—DAKO	−	−	−
PR	PgR636—DAKO	−	−	−
C-erbB-e	Polyclonal—DAKO	(1+) invasive carcinoma	−	−
		(3+) carcinoma in situ	(0)	(0)
CK5	XM26 (mouse)—Neomarkers	−	−	−
CK14	LL002 (mouse)—Thermo Scientific	+ carcinoma in situ	−	−
CKAE1/AE3	AE1-AE3—DAKO	+	+	+
			1% neoplastic cells	1% neoplastic cells
p63	4A4—DAKO	−	+	−
			10% neoplastic cells
p53	D0-7—DAKO	+	+	+
		20% neoplastic cells	40% neoplastic cells	80% neoplastic cells
Ki-67	MIB-1—DAKO	Proliferative activity	Proliferative activity	Proliferative activity
		50%	80%	90%
Vimentin	V9—DAKO	−	+	+
SMA	1A4—DAKO	−	+ focal areas	+ focal areas
Desmin	D33—DAKO	−	−	−
Myogenin	F5D—DAKO	−	−	−
Myo-D1	5.8A—DAKO	−	−	−
S-100	Polyclonal—DAKO	−	+ focal areas	−
CD68	KP1—DAKO	−	+ osteoclast-like cells	+ osteoclast-like cells

ER: estrogen receptor; PR: progesterone receptor; CK: cytokeratin; SMA: smooth muscle actin.