Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Oncological Medicine
Volume 2014, Article ID 737183, 3 pages
http://dx.doi.org/10.1155/2014/737183
Case Report

Familial Pancreatic Cancer: The Case for Prophylactic Pancreatectomy in Lieu of Serial Screening and Shared Decision Making

1Department of Surgery, Mount Sinai Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003, USA
2Department of Surgery, Mount Sinai Beth Israel Medical Center and The Pancreas and Biliary Center of New York, 37 Union Square West, New York, NY 10001, USA

Received 6 August 2014; Revised 10 November 2014; Accepted 13 November 2014; Published 20 November 2014

Academic Editor: Jose I. Mayordomo

Copyright © 2014 Mazen E. Iskandar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

At-risk family members with familial pancreatic cancer (FCaP) face uncertainty regarding the individual risk of developing pancreatic cancer (CaP) and whether to choose serial screening or prophylactic pancreatectomy to avoid CaP. We treated 2 at-risk siblings with a history of FCaP, congenital hepatic fibrosis (CHF), and jaundice secondary to a bile duct stricture. In one, a pancreaticoduodenal resection was done and in the second a total pancreatectomy. Malignancy was not present, but extensive pancreatic intraepithelial neoplasia (PanIn) 2 was present throughout both pancreata. The clinical course and literature review are presented along with the previously unreported association of CHF and CaP.