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Case Reports in Oncological Medicine
Volume 2014 (2014), Article ID 905478, 4 pages
Case Report

Clear Cell Adenocarcinoma of the Colon: A Case Report and Review of the Literature

1Department of Graduate Medical Education, Memorial Hermann Memorial City, 921 N Gessner Road, Houston, TX 77024, USA
2General and Vascular Surgery, 902 Frostwood Suite 205, Prof. Building 1, Houston, TX 77024, USA
3Department of Pathology, Memorial Hermann Memorial City, 921 N Gessner Road, Houston, TX 77024, USA

Received 30 December 2013; Accepted 22 January 2014; Published 4 March 2014

Academic Editors: Y.-J. Chen, Y.-F. Jiao, and G. P. Vandoros

Copyright © 2014 Christian Daniel Barrera-Maldonado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Clear cell adenocarcinoma of the colon has been described scarcely in the literature. It affects elderly men more commonly than women and usually appears in the left side of the colon. A Hispanic 41-year-old female came to the emergency room with abdominal pain, vomiting, and distension. Physical exam revealed generalized tenderness without peritoneal signs. Laboratory data was unremarkable. A CT scan showed an apple-core lesion in the distal colon. A flexible sigmoidoscopy revealed an obstructive mass that made further evaluation impossible. Exploratory surgery revealed a hard mass obstructing the descending colon, which was resected. Histopathology analysis with immunohistochemistry staining was positive for cytokeratin 20, cytokeratin 10, CDX2, and villin, while it was negative for cytokeratin 7, RCC, vimentin, and CD31. These results confirmed the clear cell variant of the adenocarcinoma. Clear cell adenocarcinomas usually arise from the kidneys and Müllerian organs. Immunohistochemistry is crucial for establishing the origin of these neoplastic cells. A cytokeratin 20+/7− with positive CDX2 is highly specific and sensitive for intestinal neoplastic origin. The main treatment has been surgery alone with moderately good results. More research and information about this malignancy is needed, especially in regard to prognosis and in order to provide the best treatment option.