Chemotherapy in the Setting of Severe Liver Dysfunction in Patients with Metastatic Colorectal Cancer

Table 1

Pertinent trends in laboratory investigations and clinical parameters for Cases  1 and  2.

	Case  1			Case  2
	At diagnosis	Postoperative^1	Postchemo^1	At diagnosis	Postoperative^1	Postchemo^1
Total bilirubin	1.9	9.4	18.4	—	8.4	3.9
Direct bilirubin	1.4	8.2	16.4	—	6.2	2.4
Aspartate transaminase (AST)	679	1116	1542	—	179	82
Alanine transaminase (ALT)	314	322	—	—	—	—
Alkaline phosphatase (AlkPhos)	379	579	966	—	1708	1167
Carcinoembryonic antigen (CEA)	178.3	271.9	2770	—	0.7	—
ECOG performance status	1	3	5	1	3	0-1

Postoperative and postchemotherapy laboratory investigations were roughly 1 week and 2 weeks apart, respectively.
At diagnosis, laboratory investigations for Case  2 were reportedly within normal limits.