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Case Reports in Oncological Medicine
Volume 2015 (2015), Article ID 431819, 5 pages
Case Report

Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature

1Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins University, 401 North Broadway, Suite 1440, Baltimore, MD 21231-5678, USA
2Department of Radiation Oncology, Case Western Reserve University, University Hospitals Seidman Cancer Center, Cleveland, OH 44106, USA
3Department of Neurosurgery, Johns Hopkins University, 600 N. Wolfe Street, Phipps Room 123, Baltimore, MD 21287, USA
4Department of Neurology/Neuro-Oncology, Johns Hopkins University, 601 N. Caroline Street, Baltimore, MD 21287, USA

Received 26 January 2015; Revised 16 June 2015; Accepted 17 June 2015

Academic Editor: Se-Hoon Lee

Copyright © 2015 Mohamed H. Khattab et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.