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Case Reports in Oncological Medicine
Volume 2015, Article ID 438385, 5 pages
Case Report

Peripheral T Cell Non-Hodgkin’s Lymphoma following Treatment of Hodgkin’s Lymphoma

1Department of Pathology, Inje University Ilsan Paik Hospital, 170 Joohwa-ro, Ilsanseo-gu, Goyang 411-706, Republic of Korea
2Department of Internal Medicine, Inje University Ilsan Paik Hospital, 170 Joohwa-ro, Ilsanseo-gu, Goyang 411-706, Republic of Korea

Received 15 November 2014; Revised 26 December 2014; Accepted 26 December 2014

Academic Editor: Nurdan Tacyildiz

Copyright © 2015 Sun Hee Chang and Hye Ran Lee. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Previous reports have suggested that non-Hodgkin’s lymphoma (NHL) is more likely to develop in patients with Hodgkin lymphoma (HL) compared to the general population. These two can occur synchronously or metachronously. We report here on a case of nodular sclerosis classical HL and T cell NHL that occurred in a patient metachronously. Peripheral T cell lymphoma (PTCL) of the patient was found about 2 years after treatment of classical HL. When the patient was diagnosed with HL, biopsy revealed typical RS cells, presenting positive for CD30 and CD15 and negative for CD79a and CD3 in immunohistochemistry. And PCR analysis showed IgH gene rearrangement; however, T cell receptor gene rearrangement and Epstein-Barr virus (EBV) were not detected on PCR analysis. After 2 years of treatment of HL, colonoscopic biopsy and lymph node biopsy showed CD3 positive atypical cells intermixed with small reactive lymphoid cells and plasma cells, indicating T cell lymphoma. PCR analysis demonstrated T cell receptor gene rearrangement and did not detect EBV. Although it is rare, synchronous or metachronous HL and NHL may occur. Therefore, we may need to ensure pathological confirmation, especially in case of lymphoma that did not respond to chemotherapy.