TY - JOUR A2 - Mauri, Francesco A. AU - Bilen, Mehmet Asim AU - Lin, Sue-Hwa AU - Tang, Dean G. AU - Parikh, Kinjal AU - Lee, Mong-Hong AU - Yeung, Sai-Ching J. AU - Tu, Shi-Ming PY - 2015 DA - 2015/03/15 TI - Maintenance Therapy Containing Metformin and/or Zyflamend for Advanced Prostate Cancer: A Case Series SP - 471861 VL - 2015 AB - Metformin is derived from galegine, a natural ingredient, and recent studies have suggested that metformin could enhance the antitumor effects of hormone ablative therapy or chemotherapy and reduce prostate cancer-specific mortality. Zyflamend is a combination of herbal extracts that reduces inflammation and comprises turmeric, holy basil, green tea, oregano, ginger, rosemary, Chinese goldthread, hu zhang, barberry, and basil skullcap. We propose a maintenance regimen with metformin and/or Zyflamend that targets cancer stem cells and the tumor microenvironment to keep the cancer dormant and prevent it from activation from dormancy. Herein, we report the clinical course of four patients who experienced a clinical response after treatment with metformin and/or Zyflamend. SN - 2090-6706 UR - https://doi.org/10.1155/2015/471861 DO - 10.1155/2015/471861 JF - Case Reports in Oncological Medicine PB - Hindawi Publishing Corporation KW - ER -