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Case Reports in Oncological Medicine
Volume 2015, Article ID 512849, 5 pages
http://dx.doi.org/10.1155/2015/512849
Case Report

Multiple Bone Metastases as the First Manifestation of Hepatocellular Carcinoma in Patient with Noncirrhotic Liver

1Department of Internal Medicine, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of Korea
2Department of Pathology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul 139-707, Republic of Korea

Received 9 June 2015; Revised 24 October 2015; Accepted 27 October 2015

Academic Editor: Cesar V. Reyes

Copyright © 2015 Soo Ya Bae et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hepatocellular carcinoma (HCC) generally occurs on the background of chronic liver disease. Chronic hepatitides B and C and alcoholic liver disease are well-known risk factors for HCC, and it is uncommon in noncirrhotic liver. Extrahepatic metastasis seldom occurs in patients with early stage intrahepatic HCC and isolated bone metastases as a first documented extrahepatic metastasis is unusual presentation. In this report, we present a rare case of small solitary HCC (<3 cm) in noncirrhotic liver, presenting isolated bone metastases as a sole manifestation in patient with no well-known risk factors. This case suggests that HCC should be considered as one of differential diagnoses in patient presenting with multiple bone metastases, even in the absence of liver cirrhosis.