Progression of an Invasive ACTH Pituitary Macroadenoma with Cushing’s Disease to Pituitary Carcinoma

Table 2

Tumor markers comparison between third and fourth surgeries.

	Ki-67 (%)	p53	ACTH (IHQ)
2009 (after 3rd surgery)	<5%	No evidence	>50%
2012 (after 4th surgery)	10–15%	25%	>50%

Considerations: The Ki-67 and p53 immunohistochemical exams were made with primary monoclonal antibody performed with 1 : 50 dilution, according to the manufacturer’s protocol.