Migrating Polyarthritis as a Feature of Occult Malignancy: 2 Case Reports and a Review of the Literature

Box 1

Features of cancer polyarthritis (Stummvoll et al. [3], Larson et al. [8], Caldwell and McCallum [57], and Pfitzenmeyer et al. [58]).

(i) Close temporal relationship (12 months) between onset of arthritis and malignancy

(ii) Late age at onset

(iii) Asymmetric joint involvement

(iv) Explosive onset

(v) Predominance of lower extremity involvement with sparing of wrists and small joints of hands

(vi) Absence of Rheumatoid Factor (RF)

(vii) Absence of rheumatoid nodules

(viii) No family history of rheumatic disease

(ix) Non-specific histopathologic appearance of synovial lining

(x) Absence of characterisitic radiologic lesions