Simultaneous Low- and High-Grade Primary Leiomyosarcomas in Two Separate Organs in a Thirty-Year Survivor of Hereditary Retinoblastoma

Figure 1

(a) Bladder leiomyosarcoma, H/E 200x: sheets of spindle shaped cells with disordered architecture and multiple mitotic figures. (b) Bladder leiomyosarcoma, MIB-1 immunohistochemistry, 200x: extensive MIB-1 positive cells showing high proliferative activity. Cells were also Rb, SMA, desmin, and vimentin positive, while negative results were obtained with S-100, melanin cocktail, CD117, and CD10. (c) Uterine leiomyosarcoma, H/E 200x: well-differentiated extensive low-grade leiomyomatous architecture with few mitotic figures. (d) Uterine leiomyosarcoma, MIB-1 immunohistochemistry, 200x: lower MIB-1 proliferative activity showing low-grade malignancy positive for ER and PR and negative for Rb and p53.

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