A Rare Thyroid Metastasis from Uveal Melanoma and Response to Immunotherapy Agents

Figure 3

(a) Spindle and epithelioid malignant melanoma cells (arrowheads) admixed with background residual thyroid follicular cells (arrows). Papanicolaou stain, original magnification ×400. (b) TTF-1 highlights residual thyroid follicular cells and is negative in the lesional cells (arrows). TTF-1 ICC, original magnification ×200. (c) HMB45 and (d) MelanA ICC show strong positivity in the lesional cells. Original magnifications ×200. (e) S100 ICC weakly highlights the fine intracytoplasmic pigment present in the lesional cells (arrows). Original magnification ×100.

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