TY - JOUR A2 - Gennatas, Constantine AU - Kollas, Aristomenes AU - Zarkavelis, George AU - Goussia, Anna AU - Kafantari, Aikaterini AU - Batistatou, Anna AU - Evangelou, Zoi AU - Sintou, Eva AU - Pavlidis, Nicholas PY - 2016 DA - 2016/07/18 TI - Testicular Signet-Ring Cell Metastasis from a Carcinoma of Unknown Primary Site: A Case Report and Literature Review SP - 7010173 VL - 2016 AB - Signet-ring cell carcinoma is a highly malignant adenocarcinoma consisting of cells characterized as cytoplasmic vacuoles filled with mucin. The most common primary location of this type of cancer is the stomach, but it may also be found in other organs such as prostate, testis, bladder, ovaries, or colon. To date, metastatic signet-ring cell carcinoma of unknown primary (CUP) site to the testis is an extremely rare entity in daily practice. Reviewing the literature, we have been able to detect only three cases of testicular metastases from CUP, two with histological diagnosis of a signet-ring cell carcinoma and one with an adenocarcinoma. In this short paper, we report a case of a 56-year-old man who presented to our Department with testicular mass and ascites. Following a standard diagnostic approach no primary tumor could be identified. CUP was the final clinical diagnosis, histologically characterized as poorly differentiated adenocarcinoma with signet-ring cells involving the peritoneum and the testicular structures. SN - 2090-6706 UR - https://doi.org/10.1155/2016/7010173 DO - 10.1155/2016/7010173 JF - Case Reports in Oncological Medicine PB - Hindawi Publishing Corporation KW - ER -