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Case Reports in Oncological Medicine
Volume 2017 (2017), Article ID 5103145, 5 pages
Case Report

Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma

1Department of Hematology and Oncology, Suzuka General Hospital, Yamanohana 1275-53, Suzuka, Mie Prefecture 513-8630, Japan
2Department of Hematology and Oncology, Mie University Hospital, Edobashi 2-174, Tsu, Mie Prefecture 514-0001, Japan
3Department of Pathology, Suzuka General Hospital, Yamanohana 1275-53, Suzuka, Mie Prefecture 513-8630, Japan

Correspondence should be addressed to Keiki Nagaharu

Received 5 May 2017; Revised 6 June 2017; Accepted 30 July 2017; Published 27 August 2017

Academic Editor: Gerassimos P. Vandoros

Copyright © 2017 Shinichi Harada et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tumor lysis syndrome (TLS) is an oncological emergency caused by massive cytolysis of malignant cells. This syndrome eventually induces metabolic abnormalities. TLS is observed mainly among tumors with rapid cell proliferation or high sensitivity to antineoplastic treatment. In rare cases, TLS occurs without any cytotoxic treatment. Previous reports have shown that alternative stress including proceeding infection or an operation might play a role in TLS. However, exact mechanism of spontaneous TLS remains unknown. Here, we describe a case of a 59-year-old woman who presented with dedifferentiated endometrial adenocarcinoma and developed TLS without any cytotoxic chemotherapy. Although spontaneous TLS in solid malignancies are extremely rare, clinicians should consider the possibilities of TLS especially in aggressive solid tumors.