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Case Reports in Oncological Medicine
Volume 2017, Article ID 5651064, 3 pages
https://doi.org/10.1155/2017/5651064
Case Report

Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission

Department of Obstetrics and Gynecology, Providence Hospital, Michigan State University College of Human Medicine, East Lansing, MI, USA

Correspondence should be addressed to Sasha Mikhael; moc.liamg@leahkim.ahsas

Received 2 May 2017; Accepted 2 July 2017; Published 3 August 2017

Academic Editor: Jose I. Mayordomo

Copyright © 2017 Sasha Mikhael et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The treatment of chronic myeloid leukemia (CML) with tyrosine kinase inhibitors (TKIs) in reproductive-aged women poses major dilemmas concerning its associated teratogenicity as observed in many animal studies. Much controversy exists regarding continuation versus discontinuation of its use in pregnancy with some studies suggesting safety of TKIs before and during pregnancy and others reporting toxicity and adverse outcomes. TKIs have become a well-established treatment option for CML, significantly improving prognosis, and yet have been reported to be fetotoxic. We present a case of a 25-year-old woman who achieved successful pregnancy and delivery after withholding treatment, meanwhile relapsing, eventually achieving complete molecular remission after reinitiation of high dose dasatinib.