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Case Reports in Oncological Medicine
Volume 2017 (2017), Article ID 7834702, 7 pages
https://doi.org/10.1155/2017/7834702
Case Report

Complete Response after Treatment with Neoadjuvant Chemoradiation with Prolonged Chemotherapy for Locally Advanced, Unresectable Adenocarcinoma of the Pancreas

1Department of Medicine, Division of Hematology/Oncology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
2Department of Surgery, Division of Surgical Oncology, Drexel University College of Medicine, Philadelphia, PA 19102, USA
3Department of Pathology & Laboratory Medicine, Drexel University College of Medicine, Philadelphia, PA 19102, USA
4Department of Radiation Oncology, Drexel University College of Medicine, Philadelphia, PA 19102, USA

Correspondence should be addressed to Wilbur B. Bowne

Received 17 January 2017; Accepted 26 February 2017; Published 8 March 2017

Academic Editor: Francesco A. Mauri

Copyright © 2017 Tiffany A. Pompa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Surgery is the only chance for cure in pancreatic ductal adenocarcinoma. In unresectable, locally advanced pancreatic cancer (LAPC), the National Comprehensive Cancer Network (NCCN) suggests chemotherapy and consideration for radiation in cases of unresectable LAPC. Here we present a rare case of unresectable LAPC with a complete histopathological response after chemoradiation followed by surgical resection. A 54-year-old female presented to our clinic in December 2013 with complaints of abdominal pain and 30-pound weight loss. An MRI demonstrated a mass in the pancreatic body measuring  cm; biopsy revealed proven ductal adenocarcinoma. Due to splenic vein/artery and contiguous celiac artery encasement, she was deemed surgically unresectable. She was started on FOLFIRINOX therapy (three cycles), intensity modulated radiation to a dose of 54 Gy in 30 fractions concurrent with capecitabine, followed by FOLFIRI, and finally XELIRI. After 8 cycles of ongoing XELIRI completed in March 2015, restaging showed a remarkable decrease in tumor size, along with PET-CT revealing no FDG-avid uptake. She was reevaluated by surgery and taken for definitive resection. Histopathological evaluation demonstrated a complete R0 resection and no residual tumor. Based on this patient and literature review, this strategy demonstrates potential efficacy of neoadjuvant chemoradiation with prolonged chemotherapy, followed by surgery, which may improve outcomes in patients deemed previously unresectable.