Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Oncological Medicine
Volume 2018, Article ID 3512847, 6 pages
https://doi.org/10.1155/2018/3512847
Case Report

Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions

1Department of Pathology, Cliniques Universitaires Saint-Luc, Brussels, Belgium
2Center for Human Genetics, Cliniques Universitaires Saint-Luc–Université catholique de Louvain, Brussels, Belgium
3Department of Pathology, Katholieke Universiteit Leuven, Leuven, Belgium
4Department of Orthopaedic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium
5Department of Medical Imaging, Cliniques Universitaires St-Luc, Brussels, Belgium
6Center for Human Genetics, Cliniques Universitaires Saint-Luc and Human Molecular Genetics, de Duve Institute, Université catholique de Louvain, Brussels, Belgium
7Department of Pathology, Cliniques Universitaires St-Luc and IREC, Pôle de morphologie MORF, Université Catholique de Louvain, Brussels, Belgium

Correspondence should be addressed to Hélène A. Poirel; moc.xmg@leriop-eniotna.eneleh

Hélène A. Poirel and Christine Galant contributed equally to this work.

Received 5 October 2017; Accepted 10 December 2017; Published 27 February 2018

Academic Editor: Giovann Tallini

Copyright © 2018 Géraldine Pairet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Burke, A. Sahin, D. E. Johnson, N. G. Ordóñez, and B. Mackay, “Myoepithelioma of the retroperitoneum,” Ultrastructural Pathology, vol. 19, no. 4, pp. 269–274, 1995. View at Publisher · View at Google Scholar · View at Scopus
  2. S. E. Kilpatrick, M. G. Hitchcock, M. D. Kraus, E. Calonje, and C. D. Fletcher, “Mixed tumors and myoepitheliomas of soft tissue: a clinicopathologic study of 19 cases with a unifying concept,” The American Journal of Surgical, vol. 21, no. 1, pp. 13–22, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Bell, J. J. Van der Biezen, and P. M. N. Werker, “Parachordoma: a very rare tumour of the hand,” Journal of Hand Surgery (European Volume), vol. 34, no. 6, pp. 814–816, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. J. S. Park, K. N. Ryu, C. S. Han, and Y. K. Park, “Malignant myoepithelioma of the humerus with a satellite lesion: a case report and literature review,” British Journal of Radiology, vol. 83, no. 991, pp. e161–e164, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. V. K. Jain, D. Jain, A. Jawed, A. Prasad, N. Sachdev, and S. Kumar, “Primary myoepithelioma of bone,” Pathology, vol. 42, no. 2, pp. 190–193, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. C. D. M. Fletcher, J. A. Bridge, P. C. W. Hogendoorn, and F. Mertens, WHO Classification of Tumors of Soft Tissue and Bone, IARC, Lyon, France, 4th edition, 2013.
  7. A. Verma and B. Rekhi, “Myoepithelial tumor of soft tissue and bone: a current perspective,” Histology and Histopathology, vol. 32, no. 9, pp. 861–877, 2017, [Epub ahead of print] Review. View at Publisher · View at Google Scholar · View at Scopus
  8. J. L. Hornick and C. D. Fletcher, “Myoepithelial tumors of soft tissue: a clinicopathologic and immunohistochemical study of 101 cases with evaluation of prognostic parameters,” The American Journal of Surgical Pathology, vol. 27, no. 9, pp. 1183–1196, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. B. Rekhi, M. Sable, and N. A. Jambhekar, “Histopathological, immunohistochemical and molecular spectrum of myoepithelial tumours of soft tissues,” Virchows Archiv, vol. 461, no. 6, pp. 687–697, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. C. R. Antonescu, L. Zhang, N. E. Chang et al., “EWSR1-POU5F1 fusion in soft tissue myoepithelial tumors. A molecular analysis of sixty-six cases, including soft tissue, bone, and visceral lesions, showing common involvement of the EWSR1 gene,” Genes, Chromosomes and Cancer, vol. 49, no. 12, pp. 1114–1124, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Fisher, “The diversity of soft tissue tumours with EWSR1 gene rearrangements: a review,” Histopathology, vol. 64, no. 1, pp. 134–150, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. N. P. Agaram, H. W. Chen, L. Zhang et al., “EWSR1-PBX3: a novel gene fusion in myoepithelial tumors,” Genes, Chromosomes and Cancer, vol. 54, no. 2, pp. 63–71, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Brandal, I. Panagopoulos, B. Bjerkehagen et al., “Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma,” Genes, Chromosomes and Cancer, vol. 47, no. 7, pp. 558–564, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. P. Brandal, I. Panagopoulos, B. Bjerkehagen, and S. Heim, “t(19;22)(q13;q12) Translocation leading to the novel fusion gene EWSR1-ZNF444 in soft tissue myoepithelial carcinoma,” Genes, Chromosomes and Cancer, vol. 48, no. 12, pp. 1051–1056, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. S. C. Huang, H. W. Chen, L. Zhang et al., “Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors,” Genes, Chromosomes and Cancer, vol. 54, no. 5, pp. 267–275, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. U. Flucke, T. Mentzel, M. A. Verdijk et al., “EWSR1-ATF1 chimeric transcript in a myoepithelial tumor of soft tissue: a case report,” Human Pathology, vol. 43, no. 5, pp. 764–768, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Puls, E. Arbajian, L. Magnusson, H. Douis, L. G. Kindblom, and F. Mertens, “Myoepithelioma of bone with a novel FUS-POU5F1 fusion gene,” Histopathology, vol. 65, no. 6, pp. 917–922, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. C. Martins, I. Fonseca, L. Roque et al., “PLAG1 gene alterations in salivary gland pleomorphic adenoma and carcinoma ex-pleomorphic adenoma: a combined study using chromosome banding, in situ hybridization and immunocytochemistry,” Modern Pathology, vol. 18, no. 8, pp. 1048–1055, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. C. R. Antonescu, L. Zhang, S. Y. Shao et al., “Frequent PLAG1 gene rearrangements in skin and soft tissue myoepithelioma with ductal differentiation,” Genes, Chromosomes and Cancer, vol. 52, no. 7, pp. 675–682, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. A. Bahrami, J. D. Dalton, J. F. Krane, and C. D. Fletcher, “A subset of cutaneous and soft tissue mixed tumors are genetically linked to their salivary gland counterpart,” Genes, Chromosomes and Cancer, vol. 51, no. 2, pp. 140–148, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Galant, P.-L. Docquier, G. Ameye, Y. Guiot, J. Malghem, and H. A. Poirel, “Aneurysmal bone cystic lesions: value of genomic studies,” Acta Orthopaedica Belgica, vol. 82, no. 4, pp. 768–778, 2016. View at Google Scholar
  22. F. P. Duhoux, G. Ameye, V. Lambot et al., “Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies,” PLoS One, vol. 6, no. 10, p. e26311, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. V. Havelange, X. Pepermans, G. Ameye et al., “Genetic differences between paediatric and adult Burkitt lymphomas,” British Journal of Haematology, vol. 173, no. 1, pp. 137–144, 2016. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Kurzawa, S. Kattapuram, F. J. Hornicek, C. R. Antonescu, A. E. Rosenberg, and G. P. Nielsen, “Primary myoepithelioma of bone: a report of 8 cases,” The American Journal of Surgical Pathology, vol. 37, no. 7, pp. 960–968, 2013. View at Publisher · View at Google Scholar · View at Scopus
  25. B. Rekhi, S. S. Desai, A. Gulia, A. Puri, and N. A. Jambhekar, “Intraosseous myoepithelioma: a rare, distinct tumor entity,” Indian Journal of Pathology & Microbiology, vol. 57, no. 2, pp. 269–271, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. B. Rekhi, P. Amare, A. Gulia et al., “Primary intraosseous myoepithelioma arising in the iliac bone and displaying trisomies of 11, 15, 17 with del (16q) and del (22q11)–a rare case report with review of literature,” Pathology, Research & Practice, vol. 207, no. 12, pp. 780–785, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. B. T. Dix, M. J. Hentges, K. R. Saltrick, and U. Krishnamurti, “Cutaneous myoepithelioma in the foot: case report,” Foot & Ankle Specialist, vol. 6, no. 3, pp. 239–241, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Dahéron, A. Veinstein, F. Brizard et al., “Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23),” Genes, Chromosomes and Cancer, vol. 31, no. 4, pp. 382–389, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. M. M. R. Petit, R. Mols, E. F. Schoenmakers, N. Mandahl, and W. J. M. Van de Ven, “LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family,” Genomics, vol. 36, no. 1, pp. 118–129, 1996. View at Publisher · View at Google Scholar · View at Scopus
  30. I. von Ahsen, P. Rogalla, and J. Bullerdiek, “Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15),” Cancer Genetics and Cytogenetics, vol. 163, no. 1, pp. 68–70, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. Dahlén A, Mertens F, Rydholm A, Brosjö O, Wejde J, Mandahl N et al, “Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas,” Modern Pathology, vol. 16, no. 11, pp. 1132–1140, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. X. Wang, R. Q. Zamolyi, H. Zhang et al., “Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues,” Cancer Genetics and Cytogenetics, vol. 196, no. 1, pp. 64–67, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Schwindt, T. Akasaka, R. Zühlke-Jenisch et al., “Chromosomal translocations fusing the BCL6 gene to different partner loci are recurrent in primary central nervous system lymphoma and may be associated with aberrant somatic hypermutation or defective class switch recombination,” Journal of Neuropathology & Experimental Neurology, vol. 65, no. 8, pp. 776–782, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. K. R. Crombez, E. M. Vanoirbeek, W. J. Van de Ven, and M. M. Petit, “Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2,” Molecular Cancer Research, vol. 3, no. 2, pp. 63–70, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. Z. Li, M. Jia, X. Wu, J. Cui, A. Pan, and L. Li, “Overexpression of Trps1 contributes to tumor angiogenesis and poor prognosis of human osteosarcoma,” Diagnostic Pathology, vol. 10, no. 1, p. 167, 2015. View at Publisher · View at Google Scholar · View at Scopus
  36. F. Persson, Y. Andren, M. Winnes et al., “High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2,” Genes, Chromosomes and Cancer, vol. 48, no. 1, pp. 69–82, 2009. View at Publisher · View at Google Scholar · View at Scopus