A Rare Case of Sunitinib-Induced Rhabdomyolysis in Renal Cell Carcinoma

Figure 2

Sunitinib inhibits intracellular AMP-kinase and increase myoplasmic Ca2+. Accumulation of Ca2+ will activate calpain 3 kinase that in turn cause degradation of myofibrils. Ubiquitin ligases will ubiquitinate the peptides and target them for degradation in the proteasome.