Liquid Biopsy Detects Relapse Five Months Earlier than Regular Clinical Follow-Up and Guides Targeted Treatment in Breast Cancer

Figure 2

Shrinkage of liver metastasis upon everolimus therapy. A liver CT image is shown for September 2016 displaying a liver lesion for which the location is indicated by a yellow arrow and the diameter marked by a blue dotted line (a). Since the detection of the PIK3CA N345K variant indicated an activation of the mTOR pathway, everolimus therapy was initiated. Marked shrinkage of liver metastases was observed by a follow-up CT scan three months after targeted treatment initiation (b).

(a)

(b)