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Case Reports in Oncological Medicine
Volume 2019, Article ID 6958952, 5 pages
https://doi.org/10.1155/2019/6958952
Case Report

Synchronous Ovarian and Breast Cancers with a Novel Variant in BRCA2 Gene: A Case Report

1Breast Surgery Fellowship Program, School of Medicine, CES University, Medellín, Colombia
2School of Medicine, CES University, Medellín, Colombia
3Departament of Public Health, School of Medicine, CES University, Medellín, Colombia
4Pathology and Cytology Laboratory LLC (LAPACI), Medellín, Colombia
5Epidemiology Department, School of Medicine, CES University, Medellín, Colombia

Correspondence should be addressed to Néstor Llinás-Quintero; moc.liamg@17sanilln

Received 2 March 2018; Revised 10 September 2018; Accepted 9 December 2018; Published 6 January 2019

Academic Editor: Su Ming Tan

Copyright © 2019 Néstor Llinás-Quintero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report a case of a 52-year-old female with a family history of pancreatic and colon cancers who presented with a right breast mass positive for high-grade medullar carcinoma with triple-negative biomolecular profile. Further workup was performed finding a left ovarian mass. The patient underwent laparotomy performing optimal cytoreduction on bilateral ovarian tumors; the pathology and immunohistochemistry confirmed bilateral ovary adenocarcinoma with positive peritoneal malignancy. Due to her synchronic breast and ovarian cancers, a genetic profile was performed detecting a new pathogenic variant in the BRCA2 gene: c.3606_3607del (p.Ser1203Cysfs). She was given chemotherapy with carboplatin and paclitaxel obtaining complete clinical response. Regarding her breast cancer, she had a right modified radical mastectomy and prophylactic left mastectomy obtaining complete clinical response. This case presents with an unusual subtype and difficult histologic diagnosis of a synchronic medullar breast cancer and ovary carcinoma associated with a new mutation of the BRCA2 gene.