Synchronous Ovarian and Breast Cancers with a Novel Variant in BRCA2 Gene: A Case Report

Figure 1

Immunohistochemical analysis of the breast lesion. (a) H&E 200x: central necrosis is observed, peripheral neoplastic cells with eosinophilic cytoplasm, large nuclei, prominent nucleoli, atypical mitosis, and mononuclear infiltrates. Representative micrographs (at 400x) are shown for immunohistochemical analysis of (b) leukocyte common antigen (LCA), showing positive expression in peritumoral lymphocytes. (c) Ki67 expression is detected in 60% of cancer cells; lack of expression of (d) estrogen receptor (ER), (e) progesterone receptor (PR), and (f) HER2.

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