Tiptoeing on Metastatic Adenocarcinoma of the Lung

Figure 2

Lung adenocarcinoma metastasis to the left second toe. (a, b) The H&E section shows the dermal infiltration of adenocarcinoma; the tumor cells are arranged in a glandular growth pattern. No involvement of epidermis ((a) H&E 20x; (b) H&E 200x). (c, d) The immunohistochemical (IHC) stains reveal the tumor cells to be positive for CK7 ((c) 100x) and TTF-1 ((d) 100x), while negative for CK20, CDX-2, PAX-8, and NKX3.1 (data not shown). The previous lung fine needle aspiration slides were reviewed and found to be similar to the current specimen. Taken together, the morphology in combination with the immunoprofile are consistent with metastatic adenocarcinoma of the primary lung.

(a)

(b)

(c)

(d)